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KMID : 0364820100460030303
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Korean Journal of Microbiology
2010 Volume.46 No. 3 p.303 ~ p.307
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Analysis of Integron-Associated Multi-Drug Resistance of Acinetobacter baumannii Isolated in Korea
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Kim Seong-Hwan
Choi Ji-Hye
Park Eun-Jin
Suh In-Won
Son Seung-Yeol
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Abstract
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Acinetobacter baumannii 1625, a clinical isolate identified by Vitek and 16S rDNA sequence, showed an extended resistance to most β-lactams including imipenem, kanamycin, gentamicin, tobramycin, and cephalosporins of the third and fourth generations, and produced metallo-β-lactamase (MBL) of IMP-1 type which is rare in Korea. The isolate contained a class 1 integron of about 2.5 kb in size and the integron included accA4 (aminoglycoside resistance gene), blaIMP-1 (carbapenem resistance gene), and blaOXA-2 (extended-spectrum β-lactam resistance gene) gene cassettes in order. The coexistence of IMP-1 type and OXA-2 type β-lactamase gene cassettes in an integron has not been reported in
Korea. The transformed integron rendered the E. coli transformant resistant more than eight folds against imipenem, ampicilin, piperacillin, cefazolin, cefoperazone, and aztreonam comparing to the reference strain. This study clearly showed that the extended multi-drug resistance of A. baumannii 1625 was mainly due to the integron.
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KEYWORD
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A. baumannii, carbapenem-resistance, integron, MBL
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